COVID-19

Dear Partners,

Necessitated by the unprecedented situation created by Covid-19, several industry events and tradeshows across the world have been postponed or stand cancelled. While we were looking forward to meet you, we at Piramal Pharma Solutions have had to take several precautionary measures to protect both our employees and customers, worldwide.

As we move forward in these extraordinary times, we want to assure you that that we are operational by taking the right safety measures and abundant precautions to ensure that we continue to support you and your patients.

While all of us are working remotely for now, you can schedule a discussion with us and we would be glad to help ensure you meet your pharmaceutical development and supply needs and thereby, your clinical and commercial timelines.

Please feel free to reach out to us at:
Stuart.Needleman@piramal.com

Our best wishes to colleagues, friends and family.

Best Regards,
Piramal Pharma Solutions

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Piramal’s Route Scouting Strategy is a Speedy Solution for Customers in the Early Phase Development of APIs

Success Story: Piramal’s Route Scouting Strategy is a Speedy Solution for Customers in the Early Phase Development of APIs.

The route scouting team at PDS supplied 100g of API for early phase clinical trials to a customer. Some of the noteworthy features were the medicinal chemistry route was non-scalable, unsafe and used Palladium cross coupling reaction at the last stage contributing to a high manufacturing cost apart from a potential stability issue of the final molecule.

The PDS route scouting team designed a shorter, safer route that was robust and scalable which bypassed the use of Palladium and in the process ensured the stability of the final molecule.

The new route was shorter by two steps and had an overall yield improvement by 6X with an improved purity of 99.5 %

Comparison of Med Chem Procedure vs Current Process.

No.Comparison pointsMed Chem. ProcedureRoute Scouting Process
1.No of Chemical steps86
2.No of Column chromatography60
3.Overall yield2.9 %18.9 %
4.Metals catalysisYesNo
5.ProcessComplexSimple and scalable

To achieve this exceptional success the route scouting team ensure the following:

  • Speedy literature search and proposed 3 new synthetic routes.
  • Parallel optimization of the selected route to ensure delivery of the API with high purity.

Basis of the route scouting delivery the client has since requested for multi kg scale up quantities (GMP and non-GMP) from Piramal API services which would be scaled up at Ennore (India) and Torcan (Canada).

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Customer feedback: “It is a great accomplishment and very impressive”.

Great!