Route Scouting

We assist our partners in developing cost effective, competitively advantaged, and robust chemical processes that emphasize atom efficiency and minimize waste.

A few challenges that we have previously addressed includes the following:

  • I have a medicinal chemistry route; I need to make 100--250 gms for GLP Tox studies
  • I need a robust route for Tox/Ph I; my route uses reagents that are expensive OR not available in bulk
  • My route uses toxic or hard to handle reagents
  • I have multiple chromatographic separations leading to significant loss in yields
  • I am going to face generic competition and need a cost effective route at scale to be competitive
  • I want to reduce the number of steps, or decrease the cycle time to release capacity
  • I want non-infringing route

Route Scouting Process Flow

  • Bespoke service to provide scalable routes leveraging Piramal Process Chemistry expertise globally and India based execution
  • Rapid access to targeted scaffold structures
  • Focus on speed and initial delivery of gram quantities
  • Reduce the number of steps for key intermediates to decrease the timeline for immediate scale up ensuring enough material is available for completion of medicinal chemistry activity
  • Reduction in the cost of intermediates during early screening and elimination of chemistry scale up issues from critical path during SAR studies
  • Business Model – short term FTE (1 FTE/ route)
  • Deliverable – Scalable Route + PoC (1-10g)