COVID-19

Dear Partners,

Necessitated by the unprecedented situation created by Covid-19, several industry events and tradeshows across the world have been postponed or stand cancelled. While we were looking forward to meet you, we at Piramal Pharma Solutions have had to take several precautionary measures to protect both our employees and customers, worldwide.

As we move forward in these extraordinary times, we want to assure you that that we are operational by taking the right safety measures and abundant precautions to ensure that we continue to support you and your patients.

While all of us are working remotely for now, you can schedule a discussion with us and we would be glad to help ensure you meet your pharmaceutical development and supply needs and thereby, your clinical and commercial timelines.

Please feel free to reach out to us at:
Stuart.Needleman@piramal.com

Our best wishes to colleagues, friends and family.

Best Regards,
Piramal Pharma Solutions

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DMPK services

In vitro facilities at PDS provide ADME (absorption, distribution, metabolism, excretion) services to provide faster and improved decision making points for our Chemistry clients or standalone offering to support drug discovery programs. We offer cost-efficient standardized and customized assays as per the client’s requirement for ADME parameters. Our ADME capabilities include:

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DMPK services

  • Physicochemical screening
    • Aqueous solubility (Thermodynamic and Kinetic method)
    • Log P (Octanol/water)
    • Log D (Octanol/PBS)
  • Permeability
    • PAMPA
    • CaCo – 2
    • MDCK (wild type)
  • Protein Binding
    • Plasma Protein Binding (Equilibrium Dialysis)
  • Drug Metabolism
    • Hepatocyte Stability
    • Microsomal Stability
    • Plasma Stability
  • Drug-Drug interaction
    • CYP inhibition assays (Fluorescent and LCMS/MS based)
  • Others
    • P-Glycoprotein Substrate
    • P-Glycoprotein Inhibition
    • Preliminary BCS Permeability (non-GLP)
    • Metabolite Identification (without structure elucidation)

Bioanalytical Services for Small Molecules (non-GLP)

  • Method development
  • Method Validation
  • Bio-sample analysis

In-Vitro Biology

With our state of art infrastructure , Piramal Discovery Solutions have the capabilities for biochemical and cell based assays. Assays can be developed based on program requirement.

  • Biochemical Assays
  • Types of assays are Spectrophotometric and Fluorimetric
  • Detection methods are Fluorescence (FRET, TR – FRET) and Absorbance (UV/ VIS)
  • Assay targets includes Enzymes (Kinases) and Phosphatases
      Cell - Based Assays
  • Proliferation (Tetrazolium based)
  • Death (Cytotoxicity)
    • Apoptosis (Caspase 3 & 9)
    • Necrosis (Calcein AM, Trypan blue exclusion, ATP depletion, LDH release)
  • Signaling & second messenger generation (cAMP/cGMP)
  • Chemokine/ Cytokine release (ELISA)
  • GPCRs (Functional assays)

In-vivo Biology*

  • DMPK
    • PK in rat and mouse (normal & tumor bearing animals) for IND and NDA submissions
    • Rapid Pilot PK study for early preclinical support
    • Route of administration PO, IV, IP, IM, SC, IT, etc.
    • Tissue distribution studies
    • Excretion studies
    • Bioavailability studies
    • Statistical analysis of PK data using WinNonLin
  • Pharmacology
    • Oncology models
    • Metabolic Diseases models
    • Inflammation models
  • IND/NDA/ANDA enabling safety evaluations**
    • Mammalian Toxicology
    • Genetic Toxicology
    • Safety Pharmacology
    • Immunotoxicity
    • Neurotoxicity
    • Bio-analytical

*Studies will be performed at the third party trusted collaborator

**Studies will be performed under GLP and at AAALAC accredited third party collaborator

Other Offerings

Discovery Chemistry

In-vitro ADME Service

Non-GMP Kilo lab

Analytical Support Services

Piramal Discovery Solutions (PDS) is a reputed service provider for mg to gm scale discovery chemistry. We have partnered with a range of well known pharmaceutical and biotechnology companies from Europe, USA and Japan.

In vitro facilities at PDS provide ADME (absorption, distribution, metabolism, excretion) services to provide faster and improved decision making points for our Chemistry clients or standalone offering to support drug discovery programs.

Piramal’s fully-equipped kilo-lab allows for rapid development of scalable and robust chemical processes using advanced process methodologies to provide a quick supply in the early phase of the development.

When you send PDS your chemistry work, you want to be assured that the allocated chemist(s) are fully focussed on the delivery of your chemistry. PDS achieves this through our “High Speed Delivery” process, a core element of which is our analytical support.

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