Services
Clinical Phase API - Process Development
Pharma Solutions have dedicated process development groups at Torcan (Toronto) , Mumbai and Chennai. The group has over 60 scientists at Torcan (Toronto) (erstwhile Torcan) and has over 30 years of experience in pricess development, scale –up and manufacture. Similarly the group has over 40 scientists at Mumbai and over 130 scientists at Chennai.
Typical lab scale equipment is upto 50L flasks and the teams are equipped with analytical equipment for impurities isolation and characterisation. Kilo lab scale hydrogenation equipment (200L max scale) is also available
All key reactions required for organic synthesis can be carried out in our facilities – a shortlist of some is presented below
- Suzuki and Buchwald/Hartwig coupling reactions, Sonogahira reaction and other coupling reactions catalyzed by metals – Have in house ICP to monitor metal removal
- Low temperature reactions (~ -65 °C) and high temperature reactions (200 °C)
- Hydrogenation/hydrogenolysis of Nitro group, double bond and CBZ group
- Horner-Wittig reaction
- Solid supported metal sequestering agents
- Reduction with reactive reagents (LAH, Alane, Dip-Cl, metal borohydride, borohydride exchange resin, borane, Zinc)
- Mitsunobu reaction
- CATHy reaction
- High temperature decarboxylation
- Enzymatic reaction (e.g. hydrolysis)
- Sulfur ylide chemistry
- Grignard reaction
- Bromination/ radical bromination