In Vitro & In Vivo Pharmacology

Our biology facilities have been developed to provide faster decision-making points for our chemistry clients. Since 2008, we have doubled both our capacity as well as capability to include a range of pharmacology services to evaluate activity and/or potential liability of compounds.  Currently, we are executing biology studies for several of our clients whose medicinal chemistry work is also being carried out by us; thus reducing the iterative cycle time of drug discovery and helping clients progress their compounds faster through the discovery stage.  The biology work is available on a stand-alone basis as well as part of an integrated drug discovery project.

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In vitro assays

• ADME: solubility, permeability, CYPinhibition / induction, plasma stability (across different species), different species), plasma protein binding
• Target-based: enzymatic / kinase assays, binding assays, GPCR assays
• Cell-based: ELISA, proliferation, apoptosis, phosphorylation status, insulin sensitizer assays, cytokine production assays using hPBMCs, signal transduction assays

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In vivo assays

• Collagen-induced arthritis
• Adjuvant-induced arthritis
• DSS-induced colitis
• TNBS-induced colitis
• PMA-induced psoriasis / atopic dermatitis
• IMQ-induced psoriasis / atopic dermatitis
• Diet-induced obesity model
• Fat tolerance test
• Glucose tolerance test
• STZ-induced diabetes
• Cytokine release
• Single / repeat dose acute toxicity
• Oral bioavailability / tissue distribution studies

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